Jakimowicz Lab


Dagmara Jakimowicz


  • 2018: Professor
  • Since 2009: Associate Professor at Faculty of Biotechnology, University of Wroclaw, Poland
  • 2008: Habilitation, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences,
  • 2005-2008: Assistant professor at Institute of Immunology and Experimental Therapy, Wroclaw, Poland
  • 2001-2005: PostDoc, Marie Curie fellowship, prof. Keith Chater’s group, John Innes Centre, Norwich, UK
  • 2000: PhD, supervisor: prof. Jolanta Zakrzewska-Czerwińska,Institute of Immunology and Experimental Therapy,
  • 1996: MSc, Biotechnology, University of Wroclaw

room 3.19
phone: (+48)71-375-29-26
dagmara.jakimowicz(at)uwr.edu.pl

Chromosome segregation and its coordination with cell division and other cell cycle processes

We focus on the function of the chromosome segregation proteins ParA and ParB in Streptomyces and Mycobacterium . We found that ParA interacts with polar proteins, Scy in Streptomyces and DivIVA in Mycobacterium. Studying the ParA and ParB interactions we explore the coordination of chromosome segregation with the other cell processes - cell elongation and cell division.

The function of topoisomerases and NAPs in chromosome organisation during bacterial cell cycle

Chromosome topology is dependent on the function of topoisomerases and NAP (nucleoid associated proteins). We found that in Streptomyces high topoisomerase I (TopA) processivity is essential during chromosome segregation. Now, we further explore the TopA mediated chromosome organisation during cell cycle and coordination of TopA activity with the function of other DNA binding proteins.


Team


Chromosome Topology

Marcin Szafran

Project: The role of topoisomerase I in Mycobacterium and Streptomyces


  • Since 2014: Assistant Professor, Laboratory of Molecular Microbiology, Department of Biotechnology, University of Wroclaw
  • 2014: PhD in Biochemistry, Department of Biotechnology, University of Wroclaw
  • 2008: MSc, Biotechnology of Proteins and Peptides, Department of Biotechnology, University of Wroclaw
  • 2006: BSc, Biotechnology, Department of Biological Sciences, University of Wroclaw

room 3.18
phone: (+48)71-375-26-40
marcin.szafran(at)uwr.edu.pl

Agnieszka Strzałka

Project: Chromosome dynamics in Streptomyces coelicolor


  • Since 2018: PostDoc, Department of Molecular Microbiology, Faculty of Biotechnology, University of Wrocław,
  • 2017: Ph. D., Department of Molecular Microbiology, Faculty of Biotechnology, University of Wrocław,
  • 2012: M.Sc. Molecular Microbiology, Faculty of Biotechnology, University of Wrocław,
  • 2010: B.Sc Biotechnology, University of Wrocław,

room 3.17
phone: (+48)71-375-23-93
agnieszka.strzalka(at)uwr.edu.pl

Martyna Gongerowska

Project: Searching for new proteins influencing chromosome supercoiling in Streptomyces.


  • Since 2013: PhD Student, Department of Molecular Microbiology, Faculty of Biotechnology, University of Wrocław
  • 2013: M. Sc. Molecular Microbiology, Biotechnology, University of Wrocław
  • 2011: B. Sc. Biotechnology, University of Wrocław

room 3.17
phone: (+48)71-375-23-93
martyna.gongerowska(at)uwr.edu.pl

Tomasz Małecki

Project: The influence of SMC protein on Streptomyces venezuelae chromosome organization.


  • Since 2015: PhD. Student, Department of Molecular Microbiology, Faculty od Biotechnology, University of Wroclaw
  • 2014: M.Sc Biotechnology, Faculty od Biotechnology, University of Wroclaw
  • 2012: B.Sc. Biotechnology, Faculty od Biotechnology, University of Wroclaw

room 3.18
phone: (+48)71-375-26-40
tomasz.malecki(at)uwr.edu.pl

Justyna Szymczak

Organization of segregational complex in Streptomyces


  • Since 2018: PhD. Student, Department of Molecular Microbiology, Faculty od Biotechnology, University of Wrocla
  • 2018: M. Sc. Molecular Microbiology, University of Wroclaw
  • 2016: B. Sc. Biotechnology, Faculty of Biotechnology, University of Wroclaw

room 2.25
phone: NUMER
justyna.szymczak2(at)uwr.edu.pl

Chromosome Segregation

Monika Pióro

Project: Analysis of species-specific interactions of proteins involved in segregation of bacterial chromosome


  • 2018: PH. D., Institute of Immunology and Experimental Therapy,  Polish Academy of Sciences
  • 2013: M. Sc. Molecular Microbiology, University of Wroclaw
  • 2011: B. Sc. Biotechnology, Faculty of Biotechnology, University of Wroclaw

room 3.17
phone: (+48)71-375-23-93
monika.pioro(at)uwr.edu.pl

Izabela Magierowska

Project: The role of intermolecular interactions of chromosome segregation protein ParA in Mycobacterium smegmatis.


  • Since 2018: PhD. Student, Department of Molecular Microbiology, Faculty od Biotechnology, University of Wrocla
  • 2018: M. Sc. Molecular Microbiology, University of Wroclaw
  • 2016: B. Sc. Biotechnology, Faculty of Biotechnology, University of Wroclaw

room NUMER
phone: TELEFON
izabela.magierowska(at)uwr.edu.pl

Past group members