Jakimowicz


Dagmara Jakimowicz


  • 2018: Professor
  • Since 2009: Associate Professor at Faculty of Biotechnology, University of Wroclaw, Poland
  • 2008: Habilitation, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences,
  • 2005-2008: Assistant professor at Institute of Immunology and Experimental Therapy, Wroclaw, Poland
  • 2001-2005: PostDoc, Marie Curie fellowship, prof. Keith Chater’s group, John Innes Centre, Norwich, UK
  • 2000: PhD, supervisor: prof. Jolanta Zakrzewska-Czerwińska,Institute of Immunology and Experimental Therapy,
  • 1996: MSc, Biotechnology, University of Wroclaw

room 3.19
phone: (+48)71-375-29-26
dagmara.jakimowicz(at)uwr.edu.pl

Chromosome segregation and its coordination with cell division and other cell cycle processes

We focus on the function of the chromosome segregation proteins ParA and ParB in Streptomyces and Mycobacterium . We found that segregation protein ParA interacts with polar proteins, Scy in Streptomyces and DivIVA in Mycobacterium. Studying the ParA and ParB interactions we explore the coordination of chromosome segregation with the other bacterial cell processes - cell elongation and cell division.

Chromosome topology and gene transcription

Chromosome topology is controlled by topoisomerases and nucleoid associated proteins (NAPs). We have established the role of highly processive topoisomerase I (TopA) in Streptomyces chromosome organisation and we examined its cooperation with NAPS. We also focus on the role of chromosome topology in regulation of gene expression.

The chromosome organisation during Streptomyces cell cycle

Our recent studies have revealed how the linear chromosome of S. venezuelae is folded and provided the first evidence of profound rearrangement of the bacterial chromosome during sporulation. We have also showed the role of segregation proteins, condesins and NAPs in chromosome folding.


Team


PhDs and Postdocs

Marcin Szafran

Project: Influence of changes in chromosome topology and stress conditions on gene expression during sporulation and germination of spores.


  • Since 2021: PhD student, Department of Molecular Microbiology, Faculty of Biotechnology, University of Wrocław
  • 2019: MSc, Biotechnology, Faculty of Biotechnology, University of Wrocław
  • 2017: BSc, Biotechnology, Faculty of Biotechnology, University of Wrocław

room 2.24
phone:
jakub.mikolajczyk2@uwr.edu.pl

Agnieszka Strzałka

Project: Chromosome dynamics in Streptomyces coelicolor


  • Since 2018: PostDoc, Department of Molecular Microbiology, Faculty of Biotechnology, University of Wrocław,
  • 2017: Ph. D., Department of Molecular Microbiology, Faculty of Biotechnology, University of Wrocław,
  • 2012: M.Sc. Molecular Microbiology, Faculty of Biotechnology, University of Wrocław,
  • 2010: B.Sc Biotechnology, University of Wrocław,

room 3.17
phone: (+48)71-375-23-93
agnieszka.strzalka(at)uwr.edu.pl

Martyna Gongerowska

Project: Searching for new proteins influencing chromosome supercoiling in Streptomyces.


  • Since 2013: PhD Student, Department of Molecular Microbiology, Faculty of Biotechnology, University of Wrocław
  • 2013: M. Sc. Molecular Microbiology, Biotechnology, University of Wrocław
  • 2011: B. Sc. Biotechnology, University of Wrocław

room 3.17
phone: (+48)71-375-23-93
martyna.gongerowska(at)uwr.edu.pl

Katarzyna Pawlikiewicz

Project: Spatial organisation of Streptomyces venezuelae chromosome during sporulation and germination of spores - the role of nucleoid-binding proteins.


  • Since 2019: PhD. Student, Department of Molecular Microbiology, Faculty od Biotechnology, University of Wroclaw
  • 2019: M.Sc Biotechnology, Faculty od Biotechnology, University of Wroclaw
  • 2017: B.Sc. Biotechnology, Faculty od Biotechnology, University of Wroclaw

room 2.24
phone: (+48)71-375-26-40
katarzyna.pawlikiewicz@uwr.edu.pl

Monika Pióro

Project: Analysis of species-specific interactions of proteins involved in segregation of bacterial chromosome


  • 2018: PH. D., Institute of Immunology and Experimental Therapy,  Polish Academy of Sciences
  • 2013: M. Sc. Molecular Microbiology, University of Wroclaw
  • 2011: B. Sc. Biotechnology, Faculty of Biotechnology, University of Wroclaw

room 3.17
phone: (+48)71-375-23-93
monika.pioro(at)uwr.edu.pl

Izabela Magierowska

Project: The role of intermolecular interactions of chromosome segregation protein ParA in Mycobacterium smegmatis.


  • Since 2018: PhD. Student, Department of Molecular Microbiology, Faculty od Biotechnology, University of Wrocla
  • 2018: M. Sc. Molecular Microbiology, University of Wroclaw
  • 2016: B. Sc. Biotechnology, Faculty of Biotechnology, University of Wroclaw

room NUMER
phone: TELEFON
izabela.magierowska(at)uwr.edu.pl

Past group members